Which suffix would indicate a painful condition associated with the tissue?

The suffix that indicates a painful condition associated with tissues is "-dynia." This suffix is derived from the Greek word "dunamis," meaning power or strength, which is indirectly related to pain. It is specifically used in medical terminology to describe pain in a specific part of the body or associated with a particular tissue type. For instance, "cardiodynia" refers to heart pain.

In contrast, the other suffixes have different meanings: "-osis" refers to a condition or process, often implying a disease or abnormal state without necessarily indicating pain; "-malacia" denotes the softening of a tissue or organ, which could be associated with a condition but does not imply pain; and "-megaly" signifies enlargement of an organ or tissue, also unrelated to pain. Understanding these distinctions helps clarify the context of various medical terms.