What is a change in the sequence of a DNA molecule known as?

A change in the sequence of a DNA molecule is referred to as a genetic mutation. This term encompasses any alteration in the nucleotide sequence of the genetics of an organism, which can occur due to various factors such as environmental influences, replication errors during cell division, or inherited changes from parents. Mutations can lead to changes in the characteristics of an organism and can result in different phenotypes, ranging from beneficial to harmful effects.

While the term "genetic disorder" typically describes a disease caused by a mutation or a series of mutations, it is more specific to the health implications rather than the change itself. "Somatic mutation" refers to mutations that occur in the non-germline cells and are not passed on to offspring, while "gametic mutation" refers to mutations occurring in the germ cells (sperm or eggs) and can be inherited. Therefore, while somatic and gametic mutations are types of mutations, the broader term that encompasses any change in the DNA sequence is genetic mutation, making it the correct answer.